Sentences with Up Against

The inventor realized he was up against technical challenges in creating the groundbreaking device.

In the courtroom, the defense attorney was up against compelling evidence presented by the prosecution.

The software developer was up against tight deadlines to release the latest version of the application.

The negotiator found himself up against stubborn opposition during the diplomatic talks.

The historian was up against the challenge of interpreting conflicting accounts of a historical event.

The detective was up against a web of deceit in unraveling a complicated criminal conspiracy.